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国产乙型肝炎疫苗和HBIG联合阻断乙型肝炎母婴传播效果研究

Prevention of Perinatal Transmission of Hepatitis B Virus to Infants of HBsAg-Positive HBV Carrier Mothers by Hepatitis B Immune Globulin and HBV Vaccine

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【作者】 尹德铭; 刘占旗; 马若波; 宋鸿斌; 杨逸梅; 姚秀玉; 张丽珍;

【Author】 Yin Deming et al(Department of Epidemiology, Institute of Public Health)

【机构】 哈尔滨医科大学公卫学院流行病学教研室; 中国医学科学院输血研究所; 哈尔滨医科大学一院; 哈尔滨医科大学一院;

【摘要】 本文采用乙型肝炎疫苗和HBIG,经3种不同的联合免疫方案,对阻断乙型肝炎母婴传播的效果进行了研究。结果证明,3个组联合免疫后12个月的抗-HBs阳转率为75%~90%;抗-HBs平均浓度(mIU/ml)为32.55~42.93;阻断率为80.00%~93.3%。联合免疫的效果是满意的。

【Abstract】 The efficacy of hepatitis B immune globulin(HBIG) combined with hepatitis B virus vaccine in preventing vertical transmission of HBV were investigated on 45 infants born to HBsAg-positive HBV carrier mothers. The infants were divided randomly into 3 groups with different scheme of application. It was found that the earlier the infant received HBV vaccine, the higher the anti-HBs appeared in his(her)blood and the better the effect of prevention was. The infants displaying HBsAg in their blood at birth were not effectively protected by HBIG and HBV vaccine.

【关键词】 乙型肝炎免疫球蛋白; 乙型肝炎疫苗; 垂直传播;
【Key words】 HBIG; HBV; Vertical transmission;
  • 【文献出处】 哈尔滨医科大学学报 ,Journal of Harbin Medical University , 编辑部邮箱 ,1988年05期
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