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用重组人白细胞介素2诱导人肺癌浸润淋巴细胞的LAK样活性
Induction of LAK Activity from Lymphocytes Infiltrating Human Lung Carcinomous Tissue by Human Recombinant Interleukin-2 (rlL-2)
【摘要】 <正> 淋巴细胞浸润肿瘤组织的现象已被广泛注意,但对TIL的抗肿瘤作用进行研究只是近二三年才开始。这主要是由于基因工程技术的进步,使人们可以获得大量纯一的重组白细胞介素2(rIL-2),从而可进行TIL的活化,增殖,扩增的研究。我们用人rIL-2对
【Abstract】 We Investigated antitumor activity of tumor infiltrating lymphocytes(TIL) obtained from human carcinomous tissue. The results showed: 1) a large number of TIL could be obtained from tumor tissue by methods of enzymic isolation and Ficoll gradient centrifugation. The ratio of TIL and tumor cells varied in the samples; 2) after incubation of TIL with rIL-2 lymphoblasts appeared in the culture. Aggregates consisting of fast-growing cells were observed; 3) TIL from 5 lung tumor samples demonstrated significant cytotoxic activity against NK-resistant Anip targets after co-culture with rIL-2. Further investigations on other antitumor properties of TIL are being continued.
- 【文献出处】 哈尔滨医科大学学报 ,Journal of Harbin Medical University , 编辑部邮箱 ,1988年04期
- 【被引频次】3
- 【下载频次】9