【摘要】 <正> 1986年10月1日至1987年8月31日,哈尔滨市妇产医院,我校一院、二院,哈尔滨铁路中心医院等4所医院共出生新生儿8770例,其中先天性畸形儿138例(不能排除有遗传性疾病),出生缺陷发生率为15.74‰。在各种畸形儿中,中枢神经系统结构畸形儿为57例更多还原

【Abstract】 The study was carried out in four hospitals in Harbin, from October 1, 1986 to August 31, 1987. By means of 1:2 matched case control study we surveyed 38 cases of congenital malformations of central nervous system(CMCNS) and 76 controls. 28 risk factors were analysed by methods of monofactorial analysis and Logistic regression analysis.It was found that 10 risk factors had a close relationship with CMCNS(x~2>3.84, P<0.05). And the results of co nditional Logistic regression analysis showed that maternal hyperpyrexia(G=16.080, P<0.01, RR=26.8605), contact with poisonous chemical substances (G=11.662, P<0.01, RR=7.2396)in the first trimester, contact with the harmful physical elements during pregnancy(G=6.000, P<0.05, RR=5.7703)and father drinking (G=5.804, P<0.05, RR=7.2563) were the risk factors of CMCNS.For 86.8%of cases(33/38)had a contact with one or two of the above four factors. It can be thought that in order to prevent CMCNS should be place focus on the prevention of the above four factors.更多还原