【摘要】 本文用 OKT 单克隆抗体系统微量细胞毒方法对48例寻常性银屑病患者外周血 T 淋巴细胞亚群进行测定,发现患者体内 OKT₄⁺（辅助性 T 细胞）OKT₈⁺（抑制/杀伤 T 细胞）均较正常人低,（P<0.05）,且 OKT₈⁺降低幅度大于 OKT₄⁺,故 OKT₄⁺/OKT₈⁺比值较正常人升高。作者认为:银屑病患者 T 淋巴细胞亚群比值下降和失调在该病发病的免疫机理中起重要作用。此外,本文还比较了不同病情程度及临床各期患者间 T 淋巴细胞亚群比值,结果无统计学意义。更多还原

【Abstract】 It is investigated the T-cell subpopulations of the peripheral blood of 48 cases of psoria- sis vulgaris compared with the normal subjects by the assay of OKT monoclonal antibodies in this paper.Our fidings demonstrated a statistically significant decrease in the population of suppressor T-cells(OKT8)and helper T-cells(OKT4)and increase of helper-suppressor T-cell ratio(OKT4/OKT8)in patients with psoriasis compared with healthy control subjects (all P<0.05).It is believed that the disorders of the T-cell subpopulations have close rela- tionship with the immunolegical pathogeny of psoriasis.It is also compared the differences of the T-cell subpopulations of the patients with psoriasis in different clinical activities and surface area involvements.更多还原