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银屑病患者外周血T细胞亚群测定——OKT单克隆抗体系统微量细胞毒法

Investigation of T Cell Subpopulations in Peripherial Blood of the Patients with Psoriasis——OKT Monoclonal Antibodies Combined with Cellula(?)Microdose-toxicity Technique

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【作者】 李军周光平周鸣生陈平龚其美

【Author】 Li Jun Department of Dermatology and Microbiology,West China University of Medical Sciences,Chengdu

【机构】 华西医科大学皮肤病学教研室华西医科大学皮肤病学教研室华西医科大学微生物学教研室

【摘要】 本文用 OKT 单克隆抗体系统微量细胞毒方法对48例寻常性银屑病患者外周血 T 淋巴细胞亚群进行测定,发现患者体内 OKT4+(辅助性 T 细胞)OKT8+(抑制/杀伤 T 细胞)均较正常人低,(P<0.05),且 OKT8+降低幅度大于 OKT4+,故 OKT4+/OKT8+比值较正常人升高。作者认为:银屑病患者 T 淋巴细胞亚群比值下降和失调在该病发病的免疫机理中起重要作用。此外,本文还比较了不同病情程度及临床各期患者间 T 淋巴细胞亚群比值,结果无统计学意义。

【Abstract】 It is investigated the T-cell subpopulations of the peripheral blood of 48 cases of psoria- sis vulgaris compared with the normal subjects by the assay of OKT monoclonal antibodies in this paper.Our fidings demonstrated a statistically significant decrease in the population of suppressor T-cells(OKT8)and helper T-cells(OKT4)and increase of helper-suppressor T-cell ratio(OKT4/OKT8)in patients with psoriasis compared with healthy control subjects (all P<0.05).It is believed that the disorders of the T-cell subpopulations have close rela- tionship with the immunolegical pathogeny of psoriasis.It is also compared the differences of the T-cell subpopulations of the patients with psoriasis in different clinical activities and surface area involvements.

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