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银屑病患者外周血T细胞亚群测定——OKT单克隆抗体系统微量细胞毒法
Investigation of T Cell Subpopulations in Peripherial Blood of the Patients with Psoriasis——OKT Monoclonal Antibodies Combined with Cellula(?)Microdose-toxicity Technique
【摘要】 本文用 OKT 单克隆抗体系统微量细胞毒方法对48例寻常性银屑病患者外周血 T 淋巴细胞亚群进行测定,发现患者体内 OKT4+(辅助性 T 细胞)OKT8+(抑制/杀伤 T 细胞)均较正常人低,(P<0.05),且 OKT8+降低幅度大于 OKT4+,故 OKT4+/OKT8+比值较正常人升高。作者认为:银屑病患者 T 淋巴细胞亚群比值下降和失调在该病发病的免疫机理中起重要作用。此外,本文还比较了不同病情程度及临床各期患者间 T 淋巴细胞亚群比值,结果无统计学意义。
【Abstract】 It is investigated the T-cell subpopulations of the peripheral blood of 48 cases of psoria- sis vulgaris compared with the normal subjects by the assay of OKT monoclonal antibodies in this paper.Our fidings demonstrated a statistically significant decrease in the population of suppressor T-cells(OKT8)and helper T-cells(OKT4)and increase of helper-suppressor T-cell ratio(OKT4/OKT8)in patients with psoriasis compared with healthy control subjects (all P<0.05).It is believed that the disorders of the T-cell subpopulations have close rela- tionship with the immunolegical pathogeny of psoriasis.It is also compared the differences of the T-cell subpopulations of the patients with psoriasis in different clinical activities and surface area involvements.
- 【文献出处】 华西医讯 , 编辑部邮箱 ,1988年04期
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