【摘要】 作者以甘露醇作试验糖建立了氢气呼吸试验测定小肠传递时间。45名对象分别服15及20g甘露醇后41名呼气中氢气含量明显升高(91％),用钡餐透视法作对照发现甘露醇进入盲肠后平均6.6分钟开始产氢。两法所测定的小肠传递时间具有高度相关性(r=0.80,P<0.001),说明本法准确、可靠。与国外采用的乳果糖相比,甘露醇具价格便宜、来源丰富等优点,适于国内推广应用。更多还原

【Abstract】 Mannitol was used as a test sugar toestablish breath hydrogen test (BHT) in thedetermination of small bowel transit time(SBTT) .Following an oral administrationof 15 and 20g of mannitol, breath hydrogenincreased markedly in 41 out of 45 sobjects(91%), on average in 6.6 min after theentry of mannitol-barium suspension intothe cecum. The arriving of barium meals atcecum was best correlated with the first risesof breath hydrogen in those with a singlepeak pattern and the second rise in 10 pa-tients of bacterial overgrowth (BOG) with adouble peak pattern respectively. This sug-gested that the SBTT should not be simplydefined as the time between the oral admin-istration of mannitol or any other unabsor-bable test sugar and the first rise of breathhydrogen, because the first rise in a BOGpatient was demonstrated to be formed byhydrogen gas produced in the small intestineother than the colon. So it is suggested thatmannitol-BHT should last 3 to 4 h in thedoterminnation of SBTT, so as to recognizethe pattern of breath hydrogen response.SBTT in 21 healthy subjects was 81.7±44.6min. In conclusion, mannitol-BHT iS reliableand accurate in measuring SBTT, and canbe widely used in Chine, because mannitolis abundant and much cheaper than lactulose,which is exclusively used as a test sugarabroad.更多还原