【摘要】 本文报道国产氨利酮对血液灌流犬离体窦房结与前乳头肌标本,以及麻醉犬血流动力学和心肌耗氧量的影响,并与进口品作对比。结果表明:国产氨利酮有较强的正变力作用和一定的正变时效应,对麻醉犬有增强心功能但不改变心肌耗氧量的作用。以上各效应与进口品比较无明显差异。更多还原

【Abstract】 Isolated blood-perfused canine sinoatrial（SA） node and papillary muscle prepara-tions were made from 12 dogs.Ten μg ofChina-made amrinone （AMR-C）given intra-arterially exerted no significant effects onthe SA node rate, anterior septal artery bloodflow, or atrial and papillary muscle tensionand the tension development.All the aboveparameters increased with the dose raisedto 100μg and 1000μg, and the maximumvalues were 25.4, 13.7, 101.3, 37.7 and 34.2%（all P<0.05）. There was no significantdifference between AMR-C and Americanamrinone（AMR-A） in these effects. Sixanesthetized open-chest dogs were preparedfor the measurement of the hemodynamicindices, cardiac performance and MVO₂.AMR-C 1 mg iv increased the indices of thecardiac pump function, such as CO, CI,andindices representing cardiac contractility,including ±dp/dt max, Vce cpip, but it re-duced t-dp/dt max.The cardiac tension de-termined by strain-gauge was increased by110.6% （P<0.05） .The coronary blood flowshowed a great increase of 43.0% as a resultof a decrease in coronary vascular resistance（-39.2%） .In spite of the augmentation ofcontractility, MVO₂ did not change signifi-cantly. All these observations were similarto those of AMR-A.It is therefore concludedthat AMR-C has a potent effect of positiveinotropism and vasodilatation and pharma-cologically does not differ significantly fromAMR-A.更多还原