【摘要】 作者采用呼气氢含量测定(BHT)的方法,检测了56名汉族成人对50克乳糖的耐受情况,并用经典的乳糖耐量试验作对照,其中11人作了粪便细菌产氢试验,发现乳糖吸收不良的发生率为100％;BHT的诊断率为96. 4％。结果表明,BHT可以作为临床诊断乳糖吸收不良的简便有效的方法。同时对 BHT的机理进行了探讨。更多还原

【Abstract】 With lactose tolerance test （LTT） as acontrol, breath hydrogen test （BHT） wasused to study lactose malabsorption in 20healthy adults （group Ⅰ）, 18 patients withsome abdominal symptoms but no diarrhea（group Ⅱ）, and 18 patients with chronicsmall bowel diarrhea （group Ⅲ）.During thetest the symptoms were closely observed.The hydrogen producing test of the fecalbacteria was performed among 11 subjects. The test showed that the incidence ofmalabsorption for 50 g lactose was 100%among the 56 subjects. There was no sig-nificant difference in ΔH, ΔBG and AIS（average index of symptoms） among thethree groups. There was significant positivecorrelation between ΔH and AIS（P<0.025）. Breath hydrogen markedly increasedonly when carbohydrate which was notabsorbed passed through the distal ileumand colon, and bacteria living there hadability to produce H₂ during the process ofhydrolyzing sugar.The special H₂ curve ofthe patients with small bowel bacteriaovergrowth was also found. The diagnosis rate with BHT was96.4%, which was as accurate as with LTT.The false-negative was 3.6%. But the H₂technique can detect malabsorption of avery small fraction of an ingested load andit is a simple and noninvasive method forthe diagnosis of carbohydrate malabsorptionand small bowel bacterial overgrowth.更多还原