【摘要】 本文报道^99mTc-MAG₃ 的制备、分析及初步应用。用Whatman Ⅰ号层析纸和硅胶薄板,以生理盐水为展开剂作层析,^99mTc-MAG₃ 的放射化学纯度>95％。标记后的稳定性较好,0～4 小时后的标记率均>90％。家兔肾时间-放射性曲线表明,注射^99mTc-MAG₃ 后1分钟,肾内浓聚达较大值。随着时间的推移,肾内放射性迅速下降,30分钟后肾内残存的放射性仅10％左右。肾脏显影较好。更多还原

【Abstract】 The present paper reports a method ofpreparing ^99mTc-MAG₃ （Mercaptoacetylgly-cylglycylglycine）, and its evaluation andapplication. The radiochemical purity byWhatman Ⅰ paper and silica gel thin layerchromatography with saline as elution sol-vent showed that not less than 95% of thetotal radioactivity was found in the labeled^99mTc-MAG₃.After labeling, the agentswere stable, the labeling efficiency wasover 90% within 0-4 h Our experiment studies demonstratedthat ^99mTc-MAG₃ was well concentrated inthe kidneys after the intravenous adminis-tration to the rabbits. The time-activitycurve of the rabbit’s kidney with the rab-bit’s kidney as interests showed that theradioactivity of the kidneys was higher 1minute after the injection, but with thelapse of time, the activity of the kidneysdecreased very rapidly, and only 10% wasfound 30 minutes after the injection. Thedynamic renal imaging is good.更多还原