【摘要】 作者检测了近绝经年龄尚未经绝和绝经1～10年以上健康妇女169例的血浆中促性腺激素（FSH、LH）和卵巢分泌激素（E₂、E₁、P、T）;空腹血钙、磷及碱性磷酸酶;桡骨远、中段1/3交界处的骨盐量。检测结果:完全绝经前FSH、LH开始升高,E₂、E₁、P、T开始下降;绝经后FSH、LH进一步升高,E₂、E₁、P、T迅速下降,且骨吸收大于骨形成,导致骨盐丧失。绝经头3年失骨较快,每年平均丧失2.2％,绝经3～4年后,促性腺激素和卵巢分泌激素相对稳定,失骨减慢,每年平均丧失0.73％。更多还原

【Abstract】 This paper reports the results of a studyof correlation between sex steroids and boneloss in 169 climacteric women aged 44-63.They were divided into 11 groups accordingto the menopausal year. Plasma levels ofFSH, LH, E₂, E₁, P and T were measur-ed with RIA. Bone mineral contents of theradius were determined with the techni-que of photon absorptiometry. Plasma cal-cium was determined with EDTA. Plasmaphosphate and alkaline phosphatase weredetermined with photometry at the sametime. The results are as follows: 1. In thepremenopausal stage the ovarian functionbegins to decline, E₂, E₁, P, T decreaseand FSH, LH begin to rise. In the post-menopausal period the ovarian functionfurther declines, FSH and LH further riseand E₂, E₁, P, T, decline rapidly. Threeto four years after menopause theovarian function is relatively stable; thelevels of gonadotropine and sex steroids arerelatively steady; and 2. After menopausethe bone absorption is more obvious thanbone formation, which is due to the me-chanism of bone loss after menopause.It isconcluded that lower estrogen level is themain cause of the post-menopausal boneloss.更多还原