【摘要】 用铬(Ⅲ)、烟酸、氨基酸等,在一定条件下合成多元混配配合物,并对其红外光谱、紫外光谱、Rf值、溶解度等性质进行了测定。动物试验及初步临床试验表明,本品有较好的生物活性;对高脂血症患者有明显降低血清胆固醇及甘油三酯的作用;对糖尿病患者有降低血糖的作用。急性和亚急性毒性试验表明,本品毒性较小。更多还原

【Abstract】 A mixed ligand complexes composed ofCr （Ⅲ）, nicotinic acid and amino acidswas synthesized and some of its propertiesincluding average molecular weight, solu-bility in water, infrared spectra, ultra-violetspectra and paper chromatography Rf valuewere studied. The composition of the mixedligand complexes was determined as Cr（Ⅲ）5.3±0. 3%, nicotinic acid 25.2± 3. 9%, gly-cine 12.9±0.2%, L-cysteine 5.69±0.90% andL-glutamic acid 5.09±0.60%. The test donein rabbits showed that it caused a decreaseof about 72.7% of triglycerides and 43.9%of cholesterol in their serum. Acute toxi-city: LD₅₀ in mice was 1.85±0.10/kg. Sub-acute toxicity: no significant change shownin liver and renal functions in rabbits. Thehalf-life in venous blood, was found to beabout 48 hours. The results of clinical trialin 95 patients with hyperlipoproteinemiawere consistent with those of the animalexperiments, the effective rate was 70%.Theblood sugar in 8 out of 12 diabetics de-cesed.更多还原