【摘要】 在20只肌肉麻痹、切断双侧颈迷走神经的家兔的一侧孤束核区微量注射5μg马桑内酯,引起对侧膈神经放电的吸气时程和呼气时程显著缩短,呼吸频率显著加快,但膈神经电活动的积分幅度及动脉血压与脑电图均无明显变化。此结果提示马桑内酯可能宜接刺激延髓孤束核区的呼吸有关神经元,促进呼吸时相的转换,致使呼吸频率加快。更多还原

【Abstract】 Experiments were performed on 20paralyzed, bivagotomized and artificiallyventilated rabbits.Unilateral microinjectionof coriaria lactone (5μg) into the nucleustractus solitarius (NTS) region markedlyincreased the respiratory frequency due tothe reduction of inspiratory and expiratoryduration, but did not show any significantinfluence on the amplitude of the inte-grated phrenic nerve activity. Unilateralmicroinjection of coriarja lactone into thenucleus reticularis parvocellularis (R.pc)region had no significant effect on respira-tion. At the same time significant effectsof its administration in both of the abovementioned regions on BP and EEG werenot shown. After unilateral microinjectionof coriaria lactone into the sensorimotorcortex, EEG of all the rabbits showedepileptic discharges with no significantchanges in respiration and BP. The resultssuggested that coriaria lactone might havedirect stimulation on neurons related torespiration of the NTS region, thus topromote the transition of respirationphases and cause increase in respiratoryfrequency.更多还原