【摘要】 作者给家兔静注和口服三价有机铬剂 1 mg/kg,于给药前及给药后不同时间取血,用原子吸收光谱法测得血中铬浓度,以室模型和非室模型分析法计算各药代动力学参数。结果表明:静注铬剂后其血药浓度的变化符合二室模型,T_1/2α=1.28h,T_1/2β=52.2h,V_d=1.26 （L/kg）,Cl=0.022（L/h·kg）。用非室模型法计算所得参数值与上述各数据相近。口服铬剂后其血药液度变化不符合室模型理论,故用非室模型法计算各参数。口服铬剂吸收不良,生物利用度F=4.39％。更多还原

【Abstract】 Trivalent organic chromium preparation1mg/kg was administered to 10 rabbits, 5intravenously and 5 orally. Blood wassampled at different time intervals and thechromium concentration in plasma was de-termined with an atomic absorption spec-trophotometer. Pharmacokinetic parameterswere calculated by compartment and non-compartment analysis. The results showedthat the profile of chromium blood levelafter i.v. administration conformed to thetwo-compartment model, T_1/2α=1.28h, T_1/2β=52.2 h, Vd =1.26 L/kg, Cl=0.022 L/h·kg.These values were not significantly differ-ent from those calculated by non-compart-ment analysis. The profile of chromiumblood level after oral administration did notconform to the compartment model and theparameters were therefore, calculated bynon-compartment analysis. The chromiumpreparation was poorly absorbed after oraladministration and the F value of the bio-availability was 4.39%.更多还原