【摘要】 本文报道抗癫痫新药SC1001Na静注、肌注后在家兔体内的药代动力学。作者首先对该药的体内外含量测定方法及制剂进行了研究,然后对血药时间数据进行了曲线拟合。F 值检验及理论计算值与实测值的契合程度比较均表明:该药静注与肌注给药在家兔体内的转运均符合二室开模型动力学方程。更多还原

【Abstract】 SC1001 is a new antiepileptic drug syn-thesized by professor Li Zhenghua in ourcollege. It is an organic acid.The capsulesof SC1001Na and SC1001amine are nowgiven to the epileptic patients. The pharmacokinetics of SC1001Na wasinvestigated in 9 healthy rabbits given in-travenous bolus and intramuscular injectionsin single dose crossover study. A UV-spec-trophotometry was used in the assay deter-mination of the injection and plasma sample.Plasma data were fitted to curves employingNONLIN program. The weight is 1/C~2 whereC means the plasma level of SC1001Na.According to the value of F, the da afitted the two-compartmental open model.When administered intramuscularly, SC1001Na was absorbed well from the site of in-jection giving maximum plasma level of SC1001Na varying from 145.32 to 168.07μg/ml.The half-life seen after intravenous andintramuscular administration was 6-7 h.更多还原