【摘要】 结扎家兔冠脉左室支10min、松结重灌流60min时,其血压（Bp）、左心室收缩压（LVSP）恢复程度与对照组水平相比仅差3～4%,而其心肌收缩成分实际最大缩短速度(dp/dt/p_max)、心肌收缩成分最大缩短速度(V_max)却差13.9%。硝酸甘油（NTG）静脉输入可使家兔缺血重灌注后心肌的dP/dt/p_max、V_max与Bp、LVSP快速恢复接近正常。前两项指标与对照组同类指标水平只差5.5%（P>0.05）,与不给NTG的心肌缺血组相比,有显著性差异（P<0.05）。对正常家兔静输NTG降低Bp、LVSP、左心室舒张末压（LVEDP）（P<0.05）,不改变dp/dt/p_max、V_max和心率。结果表明NTG促使缺血心肌收缩性更快的恢复。更多还原

【Abstract】 The chest-opened rabbits underwent 10 min period of occlusion of the leftventricular branches, followed by 60 min of reperfusion. During the reperfusionperiod, blood pressure (Bp)and left ventricular systolic peak pressure (LVSP)show-ed a tendency to recover obviously. AS compared with the control, by the 60thmin of reperfusion they were merely 3～4% lower, but dp/dt/Pmax and Vmax(at the 45th min of reperfusion) are 13.9% lower than the level of control. How-ever, intravenous nitroglycerin (NTG) made the dp/dt/Pmax and Vmax as well asBp and LVSP recover to nearly normal level faster, while Bp and LVSP were5.5% lower than the level of control. Thesame parameters were significantly di-fferent between the myocardial ischemic rabbits with and without intravenous NTG(P<0.05). Intravenous NTG could obviously decrease Bp, LVSP and Ieft ven-tricular end diastolic pressure (LVEDP), but did not change dp/dt/Pmax, Vmaxand heart rate (HR) in the nonischemic myocardium. Therefore, intravenous NTGmay mainly acted on ischemic myocardium. The results indicate that intravenousNTG may accelerate recovery course of impaired myocardial contractility afteracute brief coronary occlusion followed by reperfusion in rabbits.更多还原