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胃液亚硝酸盐含量与胃癌发病关系的研究

A study on the relationship between the content of nitrite in gastric juice and gastric cancer

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【作者】 周天星; 李继昌; 王智慧; 林晓银; 张瑜卿; 油书恒; 戴淑芬; 王秀彦; 赵勤;

【Author】 Zhou Tianxing et al Department of Internal Medicine, the First Affiliate Hospital

【机构】 河南医科大学一附院内科; 河南医科大学生化教研室; 郑州国棉三厂职工医院; 河南医科大学生化教研室;

【摘要】 亚硝胺类化合物致癌问题已受到普遍重视。本文表明:浅表性胃炎患者胃液亚硝酸盐含量为0.0110±0.0057mg-N/dl。胃癌患者胃液亚硝酸盐含量为0.0298±0.0243mg-N/dl,显著高于浅表性胃炎患者(P<0.002)。萎缩性胃炎患者胃液亚硝酸盐含量为0.0218±0.0220mg-N/dl,亦明显高于浅表性胃炎患者(P<0.05)。提示胃癌发病与胃液内亚硝酸盐含量增高密切相关。

【Abstract】 Attention is now universally paid to the problem of the carcinogenicity of n-nitroso compound. This article indicates that the content of nitrite in the gastricjuice of the patients with superficial gastritis is 0.0110±0.0057 mg--N/dl; that thecontent of nitrite in the gastric juice of the patients with gastric cancer is 0.0298±0.0243 mg--N/dl and is significantly higher than that of the patients with super-ficial gastritis (p<0.002). The content of nitrite in the gastric juice of the patientswith chronic atrophic gastritis is 0.0218±0.0220 mg--N/dl and is significantlyhigher than that of the patients with superficial gastritis (p<0.05). It is pointedout that there is a close relationship between gastric cancer and the increase ofthe content of nitrite in gastric juice.

【关键词】 亚硝酸盐; 胃癌; 萎缩性胃炎; 胃液;
【Key words】 nitrite; gastric cancer; atrophic gastritis; gastric juice;
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