【摘要】 本文观察了小鼠血清葡萄糖和胰岛素的正常值分别为6.11(3.36～9.86)mmol/L和8.67(0.88～22.50)μu/ml,发现两者在正常和四氧嘧啶所致糖尿病时的相互关系均为线性,并且患糖尿病时β细胞反应性较正常为低(回归系数较小)。更多还原

【Abstract】 The normal levels of serum glucose and insulin of mice fasted for 7-9hours were 6.11 (3.36-9.86) mmol/L and 8.67 (0.88-22.50) μu/ml respectively. The insulin release response was an increase of insulin from 9.81 to 21.58 μu/ml in normal mice (p<0.001) 30-60 minutes after meals, but absent in alloxan-diabe-tic mice (p>0.05).The relationship between blood glucose and insulin in normal and alloxan-diabetic mice was linear chiefly, if any. The regression coefficients were: 1.098 (p<0.05. compared with 0.252)in normal fasted mice; 2.160 in normal fasted mice mixed with normal feeded mice (30-60 min after meal). 0.252 or 0.378(P>0.05, compared with 0.252) in fasted mice into which alloxan was injected 4 or 9 days ago. The response of the p cell of pancreas to the serum glucose increase was less in alloxan-diabetic mice than that of the normal. Responses in both groups of alloxan diabetic mice (alloxan injected 4 or 9 days ago) are about the same.Because the mouse blood may be taken only once, the delay of the glucose-insulin feedback system can not be shown here.更多还原