【摘要】 用二亚硝基哌嗪诱发大鼠鼻咽癌,观察了癌变过程中各级病变的酶活性变化。乳酸脱氢酶活性从增生、化生阶段到癌前和癌变整个过程呈逐步增高;琥珀酸脱氢酶活性处于一种低水平波动,变化不显著;非特异性酯酶在增生、化生阶段活性显著增高,但到癌前和癌变阶段则明显减弱,甚至消失,变化最大,在各级病变中反应最敏感。更多还原

【Abstract】 The activities of lactic dehydrogenase (LDH), succinate dehydrogenase (SDH)and non-specific acid esterase (ANAE) of the nasopharyngeal epithelium of normal rats and their different types of lesions during the carcinogenic process treated with N, N1 -dinitrosopiperazine were studied. The reaction deposits of LDH and SDH localized mainly at the base of stratified squamous epithelium and the margin of cilia in the ciliated columnar epithelium. ANAE activity was strong in the stratified squamous epithelium, and weak in the ciliated columnar epithelium. These enzyme activities were well-distributed in the transitional epithelium. The activity of LDH increased gradually and steadily during carcinogenic process, i. e. , hyperplasia, metaplasia, pre-cancer and cancer, while ANAE showed high activity in the phase of hyperplasia and metaplasia, but lowered down or nearly disappeared in the phases of pre-cancer and cancer. The reaction of SDH was not very strong. The change of ANAE activity was the greatest in the carcinogenic process among the three enzymes and sometimes significant changes in ANAE activity had been noted before carcinogenic lesion was suspected morphologically. Whether ANAE activity might be recommended as one of the parameters for early clinical diagnosis of human nasopharyngeal carcinoma is an interesting subject to be explored.更多还原