【摘要】 本文调查了湖南省30例Graves病患者和46例健康人的HLA分布。资料表明Graves病患者组中HLAB5、Cw7、DR4、DQw3的抗原频率显著上升,HLA-A2 抗原频率比对照组低17.39％,HLA-B8 抗原频率,患者组和对照组均为O,HLA-A11和Cw4的抗原频率虽有上升,但统计学分析无显著性意义。更多还原

【Abstract】 Peripheral blood lymphocytes from 30 cases of Grave’s disease and 46 normal donors in Hunan Province had been investigated on HLA antigen. It was showed that the antigen frequency of HLA-B5, Cw7, DR4 and DQw3 increased significantly in Graves’ disease group, and their relative risk rate (RR) were 5.5, 4.1, 8.6 and 6.6 respectively, with statistic significance. On the contrary, the antigen frequency of HLA-A2 in patients’ group was 17.39%, which was less than that of the normal and the RR was 0.49 (p=0.06). HLA-B8 was not occurred in patients or controls, frequencies of HLA-A11 and Cw4 both elevated,Gontnued to p. 149 Continued from p. 148but not statistically significant. The observed association of HLA-DR4 and DQw3 with Graves’ disease is not yet reported in China. As HLA antigen frquencies are different with regard to ethnic groups, nations and districts, and different sources of typing sera carried some systemic error, and the limited examined samples, which would carry some sampling error, all these might contribute to the difference of various reports.更多还原