【摘要】 不同剂量⁶⁰Co（0、0.5、1.0、2.0、3.0与4.0Gy）照射整体小鼠及离体骨髓细胞后给锂可改善辐射对CFU-S与CFU-GM 的损伤,并降低 CFU-CM 的辐射敏感性。更多还原

【Abstract】 The whole body of mice were exposed to various doses (0, 0.5, 1.0, 2.0, 3.0, 4.0 Gy) of 60Co irradiation, with the administration of Li2CO3 (1 mEq/L, 1 ml, Ip) immediately after the irradiation and on the two successive days (Li grouup) the other group without Li treatment as control. CFU-S and CFU-GM were assayed on the sixth day after irradiation. The production rate of CFU-S and CFU-GM would becrease after irradiation, but the number of CFU-S (at 0.5-2.0 Gy) and CFU-GM (at 0.5-4.0 Gy) of Li group were significantly higher than that of the control. The radiation sensitivity of CFU-GM of the Li group (Do = 1. 65±0.17Gy) was significantly lower than that of control (Do = 1.20±0.14 Gy). The production rate of CFU-GM murine bone marrow cell (BMC) suspension exposed to irradiation in vitro was also decreased, but this could be ameliorated Significantly(at 0.5-2.0 Gy)with Li2CO3. It is suggested that lithium exerts certain protective effects on granulopoiesis of BMC and might be useful in radiotherahy,更多还原