【摘要】 用60_Coγ射线及环氧乙烷对中成药活心丹进行灭菌对比试验研究,结果表明:60_Coγ射线在4350—13050Gy剂量范围内均能达到灭菌效果,而环氧乙烷灭菌效果则不显著。环氧乙烷灭菌后细菌数仍在10000/g以上,辐照灭茵则为0—600细菌/g,符合国家卫生标准。对服用辐照活心丹的小白鼠进行耐缺氧试验,以及对家兔进行抗心律失常和抗心肌缺血等药理实验的结果表明:辐照的活心丹与未经辐照的活心丹效果相同,没有显著差异。更多还原

【Abstract】 60Coγ-ray irradiation and epoxy-ethane treatment were used to sterilize the cardiac pill.The results showed that 60Coγ-ray irradiation with the dosage of 4350 Gy-13050 Gy was more effective, while the epoxy-ethane treatment was not. By analyzing the sample, the bacterial number in cardiac pill treated with epoxy-ethane was more than 10,000 cells per gram.The cardiac pill, however, sterilized by 60Coγ-ray was only 0-600 cells/g, which completely correspond to the bacteral inspect standard of country.In this treatment, the pharmacological analysis was done with white mice and rabbits raised with irradiated cardiac pill. The results showed that there was no abnormality in the persistence of the cardiac muscle to anemia and resistance to abnormal rhythm of the heart.更多还原