【摘要】 7头猪(65.14±9.65kg)单剂量静注100mg/kg磺胺二甲嘧啶。给药后分别在不同时间间隔采集血样,用分光光度计测定血中游离磺胺浓度。血药浓度随时间变化符合开放二室模型,所得主要动力学参数为。分布半衰期(t1/2a)0.22±0.88(h);消除半衰期(t1/2)15.32±1.44(h);表观分布容积(V_d)4.8840±0.7821(100ml/kg);清除率(Cl_B)0.2221±0.0372(h×100ml/kg);药时曲线下面积(AUC)461.27±79.21(h×mg/100ml)有效血药浓度维持时间(Tcp(ther))31.14±4.39(h)。本文还根据单剂量给药参数推算了多剂量给药方案,供兽医临床参考应用。更多还原

【Abstract】 Sulfadimidine was administered to seven pigs (mean body wcigt 65.14±9.65kg) by single intravenous injection at dosage of 100mg/kg body weight.The blood samples were collected at various interval after the administration of drug. The concentrations of free sulfadimidine in blood were determined by spectrophotor-meter. A two compartment model was used to describe the time course of drug concentrations. The parameter averages were T1/2α = 0.22h, T1/2β=15.32 h, Tep (ther) =31.14h, Vd =4.8840 (100ml/kg). ClB = 0.2221 h·100ml/kg, AUC = 461.27 h·mg/100ml.According to the pharmacokinetic parameters of the single dose administration, the parameters of multiple dosage were estimated and apprcpriate dosage regimens of sulfadimidine were recommended for pigs in clinical use.更多还原