【摘要】 本工作观察了乙酰胆硷(Ach)和电刺激迷走神经对0.6N HCl引起的胃粘膜出血性损伤的保护作用,发现皮下注射50μg/kg的氯化Ach和电刺激膈下迷走神经5min,可明显降低HCl引起的胃粘膜出血量,这一作用可被消炎痛及阿托品所阻断。提示这种保护作用是通过依赖于M-受体的内源性前列腺素。更多还原

【Abstract】 The protective effect of acetylcholine ( Ach ) and electric stimulation of vagus nerve on HCL-induced gastric mucosal injuries in rats as well as the mechanism of the action was studied. The studied result showed that Ach (50μg/kg) administered subcutaneously and electric stimulation of vagus for 5 minutes could distinctly decrease gastric mucosal haemorrhage induced by instillation of 0.6N HCL, the protective property of which could be prevented by indomethacin (5mg/kg) or atropin (1mg/kg) . The result also indicated that Ach and the stimulation of vagus led to gastric protection through endogenous PGs which are dependent uponM-receptor.更多还原