【摘要】 通过乙二醇或多缩乙二醇双缩水甘油醚与氨基乙醇开环聚合,然后与γ-氨基丙基三乙氧基硅烷反应,合成了四种主链含γ-氨基丙基杂氮硅三环的聚醚聚合物。将这四种聚醚聚合物与芳香醛反应,合成了十二种主链含有γ-芳亚甲氨基丙基杂氮硅三环的聚醚聚合物。用IR、UV、~1HNMR和元素分析对它们的结构进行了验证。用体外细胞培养法测定了这些聚合物的抗肿瘤活性。更多还原

【Abstract】 Four polyethers containing γ-aminopropylsilatrane (PA_1-4 were synthesized by the reaction of ethylene glycol or polyethyleneglycol diglycidyl ether with aminoethanol and then with γ-aminopropyltriethoxysilane. Twelve polyethers containing γ-arylidene-aminopropylsilatrane in the main chain (PS_1-12) were synthesized by the condensation of PA_1-4 with arylaldehydes in toluene. The structure of these polymers were identified by IR, UV, ¹H NMR spectra and elementary analysis. Number average molecular weight was determined by vapor phase osmometer.The results of in vitro cell culture testing showed that polymers PS_1-12 exhibit certain antitumor activity.更多还原