【摘要】 育龄女妇月经周期第5天18甲炔诺酮（LNG）与血浆蛋白结合率为88.5±5.7%,与性激素结合球蛋白（SHBG）结合率为10.5±2%,肌注复方18甲炔诺酮注射液后,血浆LNG浓度迅速升高,平均达峰时间为1天,峰浓度为7.7±2.2ng/ml,以后下降,血药浓度一时间曲线符合二室模型,消除相T_1/2为6.87±1.8天。与注射前比较,LNG血浆蛋白结合率无明显改变,血浆SHBG含量于用药后逐渐下降,注射后21、29天明显低于用药前的水平,LNG与SHBG的结合率也降低,注射后21、29天与给药前也有显著差异。比较SHBG含量与SHBG结合率的变化,二者间呈正相关。更多还原

【Abstract】 Nine healthy fertile women received a single dose （im） of estradiol-levonorgestrel long-acting injectable contraceptive. After injec-tion the concentration of plasma LNG increased rapidly. The meantime of peak plasma LNG level was 1 day, the peak value of LNG was7.7±2.2ng/ml. The plasma concentration-time curve showed an open twocompartment model C=A₁e^-β₁^t+A₂ e^-β₂^t: the elimination half-life was 6. 87±1. 8 day, the time required for plasma LNG concentration to decreasebelow 100pg/ml was 33.3±5day. The plasma SHBG capacity and the per-centage SHBG bound LNG were 7.7±4.5μM/100ml and 10.5±2.0% respe-ctively, and both significantly decreased on 21st, 29th day after injec-tion. There was a positive correlation between plasma SHBG capacityand percentage SHBG bound LNG. The percentage protein bound LNGwas 88.5±3.3%, there was no significant change after injection.更多还原