【摘要】 本文简述了环硫雄醇９的改良合成法及其四个衍生物的制备（其中两个为新合成化合物），并从溴羟化产物中用分级结晶法分离得主要副产物２β─溴─３α─羟基─5α──雄甾─１７─酮６，又以６为起始原料合成２β，３β─环硫─５α─雄甾─１７β─醇１３。环硫雄醇９经药理及毒性试验表明具。有强烈抑制人乳腺癌（Ｂｃａｐ－３７）和子宫颈癌（ＨｅＬａ）细胞生长的作用；对小鼠有抗着床作用；且毒性低，副作用小。更多还原

【Abstract】 An improved method for the synthesis of EPITIOSTANOL and the prepara- tion of its four derivatives(including two new compounds )has been reported in this paper. The main by-product, 2β-bromo-3α-hydroxy-5α-androstan-17-one 6, was isolated as a bromohydrin by grade crystals method, and was then converted to 2β, 3β-Epithio-5α-androstan-17β-ol13. Studies on the pharmacological action and toxicity of EPITIOSTANOL have shown that it strongly inhibits the cell growth of breast cancer(Bcap-37)and cervical cancer(HeLa) and further more, it has anti-gestation, low toxin and less side effect.更多还原