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乙型肝炎与肝硬化和肝细胞癌的关系(HBsAg和HBcAg的定位比较观察)

The Relationship between Hepatitis B Liver Cirrhosis and Hepatocellular Carcinoma—Comparative study of localization of HBsAg and HBcAg

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【作者】 李一伟沈云英

【Author】 Li Yiwei,(Department of pathology)

【机构】 福建医学院病理解剖学教研室

【摘要】 本文应用免疫组化技术对本地区21例肝硬化和18例肝癌进行HBsAg和HBcAg标记定位的比较观察。结果显示,肝硬化组织中HBAg总阳性率为85.7%,说明HBAg与肝硬化有密切关系。肝癌组中,11例伴有HBAg阳性的肝硬化和(或)乙型肝炎。癌细胞内HBsAg阳性率为41.2%,HBcAg阳性率为11.8%,提示本地区肝癌发生与乙型肝炎、肝硬化有密切关系。

【Abstract】 By using immunohistochemistry technique, localization of HBsAg and HBcAg was investigated in 21 cases of liver cirrhosis and 18 cases of primary hepatocarcinoma. In liver cirrhosis group, 85.7% showed presence of HBAg. These indicate that there is a close relationship between HBAg and liver cirrhosis. In hepatocellular carcinoma group, 11 cases were accompanied with liver cirrhosis and/or hepatitis which showed presence of HBAg, Positive rate of HBsAg was 41.2%, and HBcAg was 11.8%. These results indicate that the onset of hepatocellular carcinoma is closely related with type B hepatitis and liver cirrhosis.

【关键词】 乙型肝炎肝硬化肝细胞癌HBsAgHBcAg
【Key words】 hepatitis Bliver cirrhosishepatocellular carcinomaHBsAgHBcAg
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