【摘要】 本文观测了135例癌症病人血清过氧化脂质(LPO)水平及两种抗氧化性维生素(V_E 及 V_C)的含量,并对二者关系进行了分析,鉴于血清 LPO 值随增龄而有升高,本文采用同龄组健康人血清观测值作对照;并选用“LPO/V_E+V_C”比值作为反映体内过氧化与抗过氧化两系统关系的指标。结果表明:癌症病人血清 LPO 水平较同龄组健康人明显增高,而其 V_E 及 V_C 含量则较正常对照组为低;LPO/V_E+V_C 比值极显著地高于对照组。作者认为 LPO/V_E+V_C 比值似可用作自由基损伤所致疾病(如癌症等)早期诊断或预后观察的一种辅助性指标。它反映了病人血清 V_E 及 V_C 的低水平与 LPO 的显著增高密切相关,并提示这类抗氧化剂对于癌症的防治可能具有积极作用,值得临床重视并予深入研究。更多还原

【Abstract】 A quantitative observation on the serum lipid peroxide(sLPO)levels and vitamin E,C(V_E,V_C)contents in 135 cases of can-cer patients has been performed.On account of the elevation of sLPOlevel with aging,the sLPO values of healthy adults at the same agehave been used as the control,and the LPO/V_E+V_C ratios have beenemployed as an indicator reflecting the relationship between peroxida-tion and antiperodxiation.The results showed that sLPO levels ofpatients were significantly higher than those of the controls.On thecontrary,the patients’ serum V_E and V_C contents were lower than thecontrols,and the LPO/V_E+V_C ratio of patients was significantly grea-ter than those of healthy ones.The authors have considered that LPO/V_E+V_C ratio could be used as a supplementary parameter for earlydiagnosis and prognosis in the diseases caused by free radicals,such ascancer patients.In addition,the lower V_E and V_C levels of the patientsmight be related to the increase of sLPO,so these antioxidants mightplay an active role in the prevention and treatment of cancer.更多还原