【摘要】 观察了31例膀胱癌患者术后的外周血NK和ADCC细胞毒活性及其对人γ干扰素(HuIEN-γ)体外调节的反应性。结果表明,这些患者平均NK活性为32.48±15。5％,与正常人比较无显著差异(P>0。05);ADCC活性平均为43±21。44％,明显低于正常人(P<0.01)。进一步用HuIFN-γ体外调节这些患者细胞毒活性,可见调节后其NK活性增高至平均53。86±21.2％,比调节前明显增强(P<0.01);ADCC活性平均增高至50.99±23.66％,与调节前比较无显著性差异(P>0.05)。24例低NK活性患者中15例的NK活性经HuIFN-γ调节后恢复至正常水平以上,占62.5％;而25例低ADCC活性患者中仅4例经调节后恢复正常,占16％。提示HUIFN-γ对NK的促进作用似强于K细胞。本研究为临床应用干扰素治疗膀胱癌患者提供了某些有参考意义的实验依据。更多还原

【Abstract】 In this paper, NK and ADCC cytotoxicity activity in 31 cases of bladder cancer after surgery and their cytotoxicity reaction to HuIFN-γ in vitro were observed.The results showed that the mean NK activity of these patients was 32.48±15.5%(P>0.05), and the mean ADCC activity was 43.0±21.44% (P< 0.01).After HuIFN-γ regulation in vitro, the mean NK activity was raised to 53.86±21.2%(P<0.01), and the mean ADCC activity, to 50.99±23.66% (P> 0.05) .The NK activity in 15/24(62.5%)cases with low NK and ADCC activity in 4/25(16.0%)cases with low ADCC were enhanced to normal level by HuIFN- γ.The results suggest that HuIFN-γ enhanced the NK activity more efficiently than the ADCC activity in bladder cancer patients after surgery.更多还原