【摘要】 46例骨髓异常增生综合征(MDS)血清铁蛋白(S.F)和白细胞铁蛋白(WBC, F)测定证明MDS病人S.F及WBC.F均值明显高于正常对照组,P值<0.01,S.F与WSC.F之间无相关性r=0.148,P>0.05。MDS不同亚型S.F测值也不同,RAEB及RAEB-T S.F均值明显高于RA组,有统计学意义,P<0.02。10例RAEB及RAEB-T有4例S.F高者均于半年内转为明显白血病。更多还原

【Abstract】 According to FAB classification 46 cases of MDS were studied from 1985 to 1987. RA 30, RA-S 4, RAEB 6, RAEB T 4 and CMML 2. Two thirds of the cases were below 40 years old. Male 34, female 12 with male female ratio of 2.8:1. 90% of the cases showed anemia, 56% leukopenia, 53% thrombocytopenia, 53% reticulcyte count less than 1%. 95% of the cases revealed normal or hypercellular bone marrow and 90% of the cases showed dyshemopoiesis. 85% of the cases showed normal or increased bone marrow stainable iron extracopuscularly and 93% did so in sideroblasts.Elevation of serum ferritin (SF) and leukocyte ferritin (WBC. F) was observed in one half and one third of the cases than normal respectively P<0.01 in both. Four of the 10 cases of RAEE and RAEB-T who had high level of SF and/or WBC. F have transformed to overt leukemia within 6 months. It’s just like acute leukemia studied in our lab., the above findings could possibly also reflect the number of leukemic cells in the body. If so, early recognition of preleukemic states is promissing.Genetic study has been done.更多还原