【摘要】 用含过氧化脂质的脂质体股静脉注射后,大鼠平均动脉压,心率和LV dp/dt_max均显著降低,氧化脂质体灌流离体大鼠心脏引起LVdp/dt_max和左室峰值收缩压显著降低,心率进行性减慢,左室峰值舒张压进行性升高,心脏挛缩以致停搏。上述体内、外实验心肌MDA含量都显著增加。结果证实,脂质过氧化物有显著的心血管抑制和损伤作用,可能参与了休克、心肌缺血的发病过程。更多还原

【Abstract】 This study was designed to investigate the effect of peroxided liposomes on the heart in vivo and in vitro, respectively. With intravenous infusion of peroxided liposomes (100 mg lipid/kg), the mean arterial blood pressure heart rate and LV dP/dt max of rats, were significantly decreased in 1-2 min, markey lower than the corresponding levels of the control group (P<0.01) which was treated with non-peroxided liposomes. Perfusion of isolated rat heart with peroxided liposomes (0.5 mg/ml) caused dramatically decrease in heart rate, left ventricular peak systolic pressure and LV dP/dt max. Left ventricular peak diastolic pressure increased and the heart fell into spasm. These results confirm that the lipid peroxides strongly inhibit cardiac function.更多还原