【摘要】 本文报道了DTPA和811对大白鼠体内钪-46的促排效果。结果表明,注射811、DTPA组大鼠使钪-46的排除途径排除量和生物半排期发生明显变化。使钪-46随粪便排除为主改变为随尿排除为主,与对照组比较,811、DTPA使钪-46的生物半排除期快排除相均缩短2.40天(对照组为4.3天),中排除相分别缩短2.77天和4.90天(对照组为9.40天),而慢排除相分别延长7.60天和8.60天(对照组为18天)。以上证明,811和DTPA早期肌肉注射对大白鼠作体内钪-46有较好的促排用,且DTPA-Ca优于811。更多还原

【Abstract】 46Sc excretion-promoting effect of DTPA and 811 in rats was reported. The results showed that a change in the excretion route and an increase in the amount of excretion were observed, and some changes in the half-life of 46Sc-DTPA and 46Sc-811 took place acoordingly. Excretion of 46Sc from urine was substituted for the ordinary excretion route from the gastrointestinal tract. When compared with the control, both DTPA and 811 shortened the fast elimination phase of the biological half-life of 40Sc by 2.4 days (4.9 days for the cotrol group),and the intermediate elimination phase by 2.77 and 4.9 days respectively (9.4 days for the control group) . However, the slow elimination phase extended over 7.6 and 8.6 days respectively (18 days for the control group). Thus, the authors believed that earlier intrarnuscular injection of DTPA and 811 will play an excellent role in promoting the exceretion of46Sc in rats, and DTPA is better than 811.更多还原