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非分泌型骨髓瘤细胞的超徽结构研究

Uitrastructural study on one case of nonsecretory myeloma

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【作者】 票振宝崔新明王乃斌张秀梅刘学明张洪盛

【Author】 Li Zhendao, Zhang Xiumei, Cui Xinming, Wang Naibin,Liu Xueming and Zhang Hongsheng (Department of Electronic Microscopy; Third Teaching Hospital)

【机构】 白求恩医科大学电子显微镜室白求恩医科大学第三临床学院白求恩医科大学第三临床学院

【摘要】 本文报告一例非分泌型骨髓瘤细胞的超微结构研究结果。用荧光抗体法检测出在90%的瘤细胞内有单克隆Ig存在。电镜观察主要发现:粗面内质网高度发达,并呈不同程度扩张;高尔基复合体明显,有很多被膜小泡。超微结构特点和临床检查结果表明:本例非分泌型骨髓瘤是属于“不分泌型”的,而不是“不产生型”的。同时,对这种类型骨髓瘤的发生机理进行了探讨。

【Abstract】 Ultrastructural study on one case of nonsecretory myeloma was reported. The electron microscopic findings showed a rather well developed rough endoplas-mic reticulum the Golgi apparatus, as well as the number of vesicles. Immu-nofluorescent study demonstrated the presence of monoclonal immunoglobulin in 90% of plasmocytes. These results suggest that nonsecretory myeloma in the present case belongs to lack of secretion, rather than lack of production of immunoglobulin.

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