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带有L6565小鼠白血病病毒的细胞系的建立

ESTABLISHMENT OF CELL LINES INFECTED WITH L6565 MURINE LEUKEMIA V蜶US

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【作者】 张雷郑葆芬陶鸿根周金涛张红丁令玫

【Author】 Zhang Lei Zheng Baofen Tao Honggen Zhou Jintao Zhang Hong Ding Lingmei( Department of BioPhysics and Chemistry, Faculty of Basic Medical Sciences, Shanghai Medical University, Shanghai)

【机构】 上海医科大学基础医学部上海医科大学基础医学部 上海上海上海

【摘要】 用L6565小鼠的胸腺、脾脏、肝脏和肾脏组织,以及外周血的无细胞提取液,分别感染NIH3T3细胞,经逆转录酶活性测定,挑选出两株感染了L6565白血病病毒的细胞,并证实L6565白血病病毒感染小鼠后主要分布于血液和淋巴系统。电镜下可观察到细胞内含有A型和C型病毒颗粒,细胞的倍增时间分别为18和16小时。细胞的XC合胞试验为阳性,在光镜下未观察到细胞的形态发生转化。收集细胞内和释放到细胞培养液中的病毒并注入新生小鼠皮下,两个月左右做血象和组织病理检查,存活小鼠全部发生了淋巴细胞型白血病。

【Abstract】 The strain of L6565 murine lymphocytic leukemia virus was established respectively with the cell-free extracts from blood, thymus,spleen,liver and kidney of L6565 mice, and two cell lines were selected by the assay of re verse transcriptase activity. L6565 Murine Leukemia Virus ( L6565-MLV )was distributed mainly in the blood and lymphatic system after infection.The two cell lines were positive in the XC Plaque Assay, and contained typical A-type and C-type virus particles. L6565-MLV did not transformfibroblasts in culture, but by inoculating the cell-free extracts of the twocell lines into newborn mice, lymphocytic leukemia was induced.

【基金】 中国科学院基金
  • 【文献出处】 病毒学报 ,Chinese Journal of Virology , 编辑部邮箱 ,1988年01期
  • 【被引频次】8
  • 【下载频次】32
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