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肺小细胞癌组织学亚型与预后的关系

THE RALATIONSHIP BETWEEN HISTOLOGIC SUBTYPES AND PROGNOSIS OF SMALL CELL LUNG CARCINOMA

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【作者】 陈慧漪; 王安潮; 李宗琴; 吴继雄; 李涤臣;

【Author】 Chen Huiyi, et al.(Department of Respiratory Diseases, Affiliated Hospital of Bengbu Medical College, Anhui)

【机构】 蚌埠医学院附院呼吸病科; 蚌埠医学院病理解剖学教研室;

【摘要】 本文对54例肺小细胞癌的组织学亚型与预后的关系进行了探讨。影响肺小细胞癌预后的因素很多,如病变范围,治疗方案等均有关。经治疗取得缓解的患者,其缓解时间及存活期的中位数,两亚型均无差异。在完全缓解的病例中,中间细胞型的比燕麦细胞癌较长,但无统计学意义。本病对治疗的反应,化疗合并放疗比单用化疗较好。燕麦细胞癌比较敏感,而中间细胞型缓解不如燕麦细胞癌多,可能与病变广泛较多有关。未作抗癌治疗的病例,病变广泛者两亚型均仅可存活3~4周;而病变局限者则可存活21~45周,尤以中间细胞型存活较长。

【Abstract】 The relationship of histologic subtypes and prognosis of small cell lung carcinonsa(SCI.G ) is evaluated in 54 patients. Many factors are associated with the prognosis of SCLC, such as the extent of turner and the regime of treatment except histrologic subtypes. There i no significant difference in the median, of duration of remission and survival in therapy-remit ted patienis. But in complete reritted pati-ents the duration of remission and survival seers longer in the patients with oat cell carcinoma than in the with intermediate cell subtype.The response to therapy of SCLC patients seens better in ones treated with chemotherapy and radiotherapy than in those with chemotherapy alone. It teems more susceptible in pationts with oat cell carcinoma, but it also referable to extent of tunor. In untreated patient, both subtypes in extensive extent may survive Only 3~4 weeks, and the survival of patients with local extent may by 21~45 weeks, and longer with intcrmediate cell Carcinona. The cases are not sufficient in this group, and more patients must be accnulated for further evaluation.

  • 【文献出处】 蚌埠医学院学报 ,Journal of Bengbu Medical College , 编辑部邮箱 ,1988年02期
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