【摘要】 晚期鼻咽癌59例分别采用日本化药公司生产的顺氯氨铂(DDP)水溶液注射剂及匹来霉素(PEP),即DP方案及云南生产的DDP及氟尿嘧啶,即DF方案治疗。结果表明DP组39例中26例(66.7％)获部分缓期(PR),另有9例(23％)稍有效(MR);DF组20例中6例(30％)获PR,另9例(45％)MR。统计学处理表明DP组疗效比DF组为优(P<0.02)。胃肠道反应为最常见副作用。白血球减少不严重。DP组可见发熱(28.2％)、皮诊(7.7％)及较多的脱发反应(36％);DF组可见静脉炎(45％)。更多还原

【Abstract】 59 cases of advanced patients with nasopharyngeal cancer (NPC) weretreated by DP regimen, consisted of cisplatin (DDP) aqueous injection and pepbmycin, both produced by Nippon Kayaku Co Japan; or by DF regimen, consisted of DDPaqueous injection, produced in Yunnan province and fluorouracil. It was shown that among 39 cases treated by DP regimen 26 (66.7%) showed partial remission (PR), in addition, 9 showed minor response (MR): among 20 cases treated by DF regimen 6 (30%) showed PR and 9 (45 %) MR. The therapeutic effeact was better in DP group than that in DF group. The difference was significant statistically.(P<0.02). Gastrointestinal reaction was the most common side effect. The leukopenia was not serious. Fever (28.2%), skin rash (7.7%) and more fr-equent alopecta (36%) was encountered in the DP group while plebitis (45%) was encountered in the DF group .更多还原