【摘要】 本研究应用图像分析技术,对肝细胞不典型增生(LCD)DNA含量及其形态特征,包括核面积、核周长、核最大直径及核等圓度直径,进行了定量测定。结果显示,与正常肝细胞相对照,LCD DNA含量水平明显增高,其细胞群体DNA含量的分布范围明显增宽;细胞核形态特征定量参数明显增大,但多介于正常肝细胞与肝癌细胞之间;LCD的核不规则指数(IN)也未达到肝癌细胞核的程度。提示LCD是一种处于异常增殖状态的癌前病变。更多还原

【Abstract】 DNA content and morphological features, including nuclear area, nuclear periment, maximal nuclear diameter and nuclear circle diameter, in cases of liver cell dysplasia (LCD) and hepatocellular carcinoma (HCC) were quantitatively determined by means of image analysis technology. The results showed that in comparision with normal hepatocytes,LCD had markedly increased DNA content and nuclear quantitative parameters, but the values were lower than those of HCC.LCDshowed sight increas in nuclear atypia, represented by nuclear irregular index, which was far from the degree of HCC. These findings indicate that LCD may be a precancerous lesion of HCC, which is in abnormal active proliferative state.更多还原