【摘要】 本文报道应用30mg的二亚硝基哌嗪作为始动因子,用对EB病毒有漱活作用的黄芜花作为促进因子,进行诱发大鼠鼻咽癌的实验。将89只二月龄大鼠分为四组:A、二亚硝基哌嗪+黄芫花组;B、黄花芫组;C、二亚硝基哌嗪组;D、空白对照组。分别给药,停药后连续观察257～330天,处死、取完整鼻咽连续切片检查。结果表明:在二亚基哌嗪+黄芫花组存活的22只大鼠中,有三例鼻咽粘膜发生癌变(一例为原位癌,二例为早期浸润癌),发癌率达13.6％。其余三组均未见癌发生。因此,黄芫花在此诱癌过程中很可能起促癌因子的作用。临床上对黄芫花似宜慎用。更多还原

【Abstract】 Using 30mg DNP as a tumor initiator, and Wikstroenia chamaedaphneMeise that has activating action on EB virus as a tumor promotor, the authors have done an experiment in inducing Nasopharyneal Carcinoma (NPC) in rats. 89 rats were divided into four groups: A. DNP+Wikstroemia chamaedaphne Meise group: B. wikstroemia chamaedaphne Meise group; C. DNP group; D. Control group. All rats were continuously observed for 257-330 days after stopping administration of the drugs. They were sacrified , the whole nas-opharyngeal cavity were taken off , then were observed by continuous sections. The results indicate that among 22, survived rats in the DNP + Wikstroemia chamedaphne Meise group 3 had carcinoma in their nasopharyngcal mucosa (1 was carcinoma in situ, 2were early infiltrating carcinoma), the tumor incidence was 13.6%. In the other three groups no carcinoma was found. As a result Wikstroemia chamaedaphne Meise likely plays a role of tumor promotor in the process of carcinogenesis.更多还原