【摘要】 将S-180肉瘤匀浆接种在瑞士小鼠的腋窝,并分为两组。一组每日静脉注射Ge-132 100 mg/kg,另一组仅作对照组。两组分别于5天及12天后杀死,取出瘤组织进行光镜及电镜检查观察,部分做G6 PDH,LDH组织化学。结果表明在治疗组与对照组相比,肿瘤的体积较小,瘤细胞的核分裂数减少。组织化学则见治疗组G6 PDH及LDH较对照组活性减弱。电镜下见治疗组的瘤细胞细胞器减少,核多见固缩状,线粒体有沉积物,胞膜变平直等表现。这些改变均支持Ge-132能抑制瘤细胞的生长。本文并对其抗肿瘤作用机制加以讨论。更多还原

【Abstract】 40 Swiss mice were transplanted with S-180 sarcoma cell suspension inthe axillary region and were divided into 2 groups, one group received Ge-132 100mg/kg I.V. daily, the other group served as control. One half of the animals in both group were sarci-ficed 5 days and 12 days after transplantation.respectively. The tumors were examined und- er light and electron microscopy, and some were stained for G6-PDand LDH histochemical-ly. The results showed that in the treated group the size of the tumor were smaller and the number of mitosis of tumor cells decreased as compared with the control group. The activity of G 6-PD as well as LDH were lower in the tumor cells of the treated group. Under electron microscope, tumor cells in treated group exhibited reduced organelles in their cytoplasm, associated with frequent pyknosis of nuclei, dense deposit in mitochondria and smoothness of their cytoplasmic membranes. All these changes indicated that tumor cells in the treated group were obviously suppressed by the action of Ge-132.The mechanism of anti-tumor activity was also discussed.更多还原