【摘要】 在混合培养体系中,部份人成纤维细胞样细胞株,尤其人胚肌成纤维细胞株能抑制被测的大多数Burkitt淋巴瘤(BL)细胞系和人黑色素瘤(MM)细胞系;但不能抑制类淋巴母细胞系(LCL)和大多数人白血病细胞系。此效应具时间和细胞浓度依赖性。将被抑制的肿瘤细胞从混合培养体系中取出,洗涤后再悬于新鲜培养液中,肿瘤细胞生长有一定程度恢复。用成纤维细胞样细胞的洗液也可证明其抑制活性,它对链霉蛋白酶敏感。更多还原

【Abstract】 The growth of 7/9 Burkitt’s lymphoma (BL) cell lines and 5/6 human melanoma cell lines was inhibited by certain human fibroblast-like cell lines, especially human myofibroblast cell lines.In contrast to BL lines, lympho-blastoid cell lines were less susceptible and 3/4 human leukemic lines were resistant.The effect was time and cell density dependent. Co-cultivation led to inhibition of tumor cell growth within 3 days,but after removal from the fibroblasts, washing and resuspending in fresh medium some tumor cells recovered and their growth improved.The inhibitory activity was also demons-trated in washings of fibroblast-like cell lines, and was sensitive to pronase.更多还原