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EB病毒壳抗原-免疫球蛋白A诊断试剂盒的研制

Diagnostic Kit on Epstein-Barr Virus Capsid Antigen Immunologlobulins A

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【作者】 谭成汉简少文姚庆云李满技罗惠玲

【Author】 Tan Chenghan Jian Shaowen Yao QingyunLi Manzhi Luo Hulling (Cancer Institute, Sun Yat-sen University of Medical Sciences)

【机构】 中山医科大学肿瘤研究所中山医科大学肿瘤研究所

【摘要】 <正> 鼻咽癌是最常见于中国南方,如广东、广西、湖南、福建、江西等省和东南亚一些国家。自酶联免疫吸附分析法问世之前,诊断鼻咽癌的方法是依据临床表现及活体组织检查,这种方法未能早期发现鼻咽癌病人。自Old等报告EB病毒与鼻咽癌有血清学关系后,Henle等报告EB病毒壳抗原—免疫球旦白A(VCA-IgA)对诊断鼻咽癌有特异性,

【Abstract】 Nasopharynged Carcinoma (NPC) is one of the most common malignancies in Guangdong provinice. High positive rate of VCA-IgA of EB Virus was found in the NPC patients. In order to facilitate the screening and diagnosis of NPC, the diagnostic kit for VCA-IgA were produced in our laboratory.In this paper the mathod of production and the use of the diagnostic kit was described. The kit was compared with that made in other laboratory in China. The positive rates using our diagnostic kit was similar to those using the diagnostic kit made by Institute of Virology, Chinese Academy of Medical Sciences (now named Centr of Preventive Medicine), but lowes than those using the kit made by Shanghai Vacine and Serum Institute. The results suggested that the specificity the kit made by us is good.

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