【摘要】 <正> 乳腺癌是妇女常见恶性肿瘤,对其超微结构的研究,文献上虽屡有报导,但其中不少问题尚存在分歧。本文利用透射电镜对乳腺癌中最常见的浸润型导管癌进行观察。对其超微结构特点、组织发生学以及肌上皮细胞,肌纤维母细胞在乳腺癌发生发展过程中的作用等方面进行了讨论。更多还原

【Abstract】 An ultrastructural study on infiltrating ductal carcinoma of the breast was reported. The tumor cells possessed such aspects as intracellular lumina, secretory granules and tubular form- ation, all of which suggest that infiltrating ductal carcinoma derived from the ductal epithelium of the breast. Three types of tubular formation were observed, i. e. classical gland, bile-capillary-like gland and tubular-like structure. Intracellular lumina and tubular-like structure presenting in infiltrating ductal carcinoma of breast are of quite characteristics, which reflect the tumor cells remaining the ductal epithelial origin with fdisturbance of differential orientation. Observations also suggest that intracellular filaments of the tumor cells belong to the intermediate filaments of epithelium, i, e. tonofilaments, probably relating to squamous metaplasia of the tumor cells. Myoepithelial cells, showing degenerative changes due to compression by tumor cells, are of the rudiments of the normal mammary ducts. Myofibroblast in stroma is likely originated from the transformation of fibroblast stimulated by the tumor cells. It may reflect the local reaction of the host against the tumor. No evidence was found to suggest that myofib-roblasts were transformed from myoepithelial cells.更多还原