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新酮醛、新鱼腥草素和多种植物多糖对体外培养鼻咽癌细胞和Hela细胞的作用及其与癌细胞内cAMP-PDE活性变化关系

The Effects of New-Keto Aldehyde, Neohouttuyninum and some Plant Polysacharides on CNE-1, CNE-2, and Hela Cells Growth and on cAMP-PDE Activity in these Tumor Cell in vitro

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【作者】 曾熙兰; 刘秀琴; 刘长征; 陈炳生; 简志瀚; 潘伟雄; 杨惠玲;

【Author】 Zeng Xilan Liu Xiuqin Liu ChangzhengChen Bingsheng (Department of Nuclear Medicine)Jian Zhihan Pan Weixiong Yang Huiling (Department of Pathopysiology)

【机构】 中山医科大学核医学教研室; 中山医科大学病理生理教研室; 中山医科大学病理生理教研室;

【摘要】 <正> 近十余年来国内外已注意到一些天然来源的中草药和植物多糖有非特异性免疫刺激作用及抗肿瘤效应,临床实验也表明某些中草药和植物多糖与促进机体免疫功能和抗肿瘤关系密切。我们前文已报道,新鱼腥草素对小白鼠移植型肝癌及艾氏腹水癌有抑制作用并可升高癌细胞内cAMP水平。中山医科大学化学

【Abstract】 Our experiments have shown that New-Keto aldehyde and Neohouttuyninum could inhibit the growth of CNE-i, CNE-2, and Hela tumor cells in vitro, they also inhibited the activity of cAMP-PDE. Both the inhibitions are strengthened with the increasing of their medical doses.These resultes indicated that the inhibitory effects of New-Keto aldehyde and Neo-houttuynimum on the cancer cells in vitro may be related to inhibition of the activity of cAMP-PDE mudulating the level of cAMP in the tumor cells.

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