【摘要】 <正> 甜菊,学名:Stevia rebaudiana Bertoni,原产于南美。在原产地作为甜茶饮用已有近百年的历史。目前已成为一种低热量、高甜度的天然饮料,广泛应用于食品工业。我国于80年代引进种植与应用。在应用过程中发现有降压作用。为此,我们对甜菊进行初步的心血管药理研究。证明甜菊总甙有轻度温和的降压作用。现报道如下:更多还原

【Abstract】 Stevioside (SV) which is extracted from Stevia rebaudiana Bertoni has been used as a replacement of sugar since 1970s, because it is a low caloric and high sweet substance. A few papers reported that SV had hypotensive effect on some hypertensive patients recently in China. In normotensive animals (cats, rabbits and rats) we found that the blood pressure decreased about 8~30mmHg after intravenously administration of SV in the dose from 50 to 200mg/kg. The hypotensive effect is dose dependence. This effect generally onsets immediately and lasts for 5-10 minutes. The heart rate and ECG are no significantly changed by SV. After cutting both vagal nerves in neck or pretreament with large dose of atropine or benadryl SV still lowers blood pressure in rats. The response to adrenaline and contractive activity of nictitating membrane induced by electronic stimulation on preganglionic fibers in cats remain normal after given SV. SV has no significant effect on isolated rat hearts and blood vessels in isolated rabbit’s ears. But small dose of SV can lower blood pressure in rats after injecting directly into the brain lateral ventricle. We concluded that’SV would lower blood pressure in animals. The cental nervous system seems responsible for this effect.更多还原