【摘要】 <正> 电刺激造成的应激反应可以明显抑制大鼠腹腔Mφ释放H₂O₂的功能,这种抑制作用可能与内源性阿片样物质及垂体-肾上腺皮质轴分泌的激素有关。本文进一步观察了更多还原

【Abstract】 The functional changes of different immune cells after severe exercise in rats andin humans were observed.In rats exercised exhausting with a load on the tail for2h,the hydrogenperoxide（H₂O₂）release from peritoneal macrophages was significantlydecreased from 16.5±0.99nmol/2×10⁶ cell·hour to 12.3±1.27nmol/2×10⁶ cell·hour.This supperssive effect could be partly reversed by subcutanous injection of opiateantagonist naltrexone（10mg/kg）.In healthy volunteer exercised bicycle ridind for1.5h,the number of T lymphocytes and monocytes in peripheral blood was signifi-cant lowered,the erythrocyte-rosette percentage of T lymphocytes was reduced from59.21±2.92% to 49.3±2.62%（p<0.05）,and auto-lymphocyte mixed reaction wasdecreased from 12724+2001 cpm to 6135+2212 cpm（p<0.05）.The results suggest thatsevere exercise may suppress the functions of different immune cells and that endo-geneous opoioids may play important roles in mediating this effect.更多还原