【摘要】 <正> IL-2通过激活和增强NK细胞、CTL和非特异性杀伤细胞(LAK)的活性,在免疫监视中起着十分重要的辅佐作用,动物实验亦证明,恶性肿瘤的发生、发展、转移和预后与IL-2活性有密切关系。因此,探讨IL-2的活性与恶性肿瘤的关系,已成为肿瘤免疫的重要研究课题之一。Rey等更多还原

【Abstract】 The capacity to generate iaterleukin-2(IL-2)of,and autologous rosette forming cel-ls(ARFC)ratio of 46 cancer patients(29 nasopharygeal carcinoma,11 lymphoma and6 leukemia)were studied.A several important things have been found as follows:(1)There was a significant decrease in capacity of cancer patient peripheral blood mono-nuclear cells(PBMC)to generate IL-2 after being stimulated for 48 hr by PHA(18%,whencompared to controls;P<0.01);(2)Generation of IL-2 by PBMC was not significant bet-ween NPC,lymphoma and leukemia(4.8 u/ml,6.3u/ml and 6 u/ml;respectively,P>0.05);(3)The cancer patient plasma could markedly inhibit IL-2 generation,but control plasmadid not.This result suggested that the patient plasma contain immunosuppressive fact-or(s)which can block IL-2 generation;(4)ARFC ratio in cancerpatients was greatlylower than that of controls(10% and 22% respectively;P<0.001);(5)ARFC ratio signi-ficantly correlated with IL-2 generation activity in cancer patients(r=0.63,P<0.001)and controls(r=0.49,P<0.001).This result demonstrated that ARFC are main cells in-volved in IL-2 generation更多还原