【摘要】 <正> 被动输入淋巴细胞作为一种肿瘤免疫疗法曾盛行于七十年代,但由于效果不确实而未能推广应用,甚至连T细胞在免疫监视上的作用也被怀疑和否认。1982年NCI的Rosenberg等首次发现在白细胞介素Ⅱ存在下培养的淋巴细胞具有杀伤肿瘤细胞的作用,命名为淋巴因子活化性杀伤细胞更多还原

【Abstract】 Lymphokine-activated killer cells （LAK） were induced from normal splenocytes with IL-2. Passive administration of LAK cells inhibied the formation of experimental pulmonary metast asis of a mammary carcinoma （SST—2） in SHR rats and the survival times of the tumor-bearing animals were prolonged. According to the result of in vitro ⁵¹Cr-release, it was clear that LAK cells could kill SST—2 cells. A more effective result was obtained when a combination of LAK cells and IL—2 was used.更多还原