【摘要】 本文报道乙基西索米星对548株临床分离菌的体外抗菌作用,并与庆大霉素、妥布拉霉素和丁胺卡那霉素进行比较。丁胺卡那霉素对革蓝氏阴性杆菌的作用最强。乙基西索米星对金葡菌和其他革蓝氏阳性球菌(除肠球菌外)具良好抗菌作用,为四种氨基糖苷类抗生素中作用最强者。乙基西索米星对肠杆菌科细菌的作用与妥布拉霉素相似,但较庆大霉素强,为四者之中对绿脓杆菌的作用最差者。对庆大霉素、妥布拉和丁胺卡那霉素耐药的金葡菌中仍有40～86％的菌株对本品敏感,对庆大霉素和妥布拉霉素耐药的革蓝氏阴性杆菌中仍有30～46.8％的菌株对本品敏感。 鉴于临床致病菌对庆大霉素的耐药率逐渐增加,乙基西索米星对于国内临床上耐药革蓝氏阴性杆菌的作用及其机理值得进一步研究。更多还原

【Abstract】 The in vitro activity of netromycin was tested and compared with that of genta-micin, tobramycin and amikacin against 548 strains of aerobic clinical isolates.Netromycin has good activity against Staph.aureus and other Gram positive cocci except enterococci, being the most active one of the four aminoglycosides tested.The activity of netromycin against different bacteria of the family Enterobacteriaceae is similar to that of tobramycin but more active than gentamicin; it is the least active one against Ps. aeruginosa in comparison with gentamicin, tobramycin and amikacin. About 25-86% of Gram positive cocci and 0-46% of Gram negative bacilli strains resistant to the other three aminoglycosides are still sensitive to netromycin. Further work is needed to elucidate the responsible mechanisms and to evaluate its potential usage in clinics.更多还原