【摘要】 大鼠42只按体重均分 7组,每组 6只,分别给以ACMA、ACMB和 ADM小鼠急性LD50的1/10及1/60剂量,另一组为生理盐水对照组。连续腹腔给药 7天后,检查大鼠的外周血象和骨髓有核细胞的变化。 1/10 LD50剂量组的ACMA和ADM外周血液内白细胞数显著下降,且ACMA组中性分叶核白细胞百分率显著降低。两剂量组的骨髓有核细胞计数明显的减少,其中 ACMA 3mg/kg组的骨髓增生程度为 2例低下、4例极度低下,粒系细胞的抑制尤为显著。而等毒剂量的ACMB组对大鼠外周血象与骨髓有核细胞与NS对照组比较均无显著差异。 因此,虽然ACMB对小鼠的急性毒性比ACMA大一倍多,与ADM相当,但以等毒剂量比较它们对大鼠骨髓造血功能的影响则以ACMB为最轻。更多还原

【Abstract】 42 rats were divided into 7 groups(6 rats per each group) and six group of them were treated with different dosages of 1/10 and 1/60 of LD50 (mice i. p.)of two different dosages of ACMA(3, 0.5 mg/kg),ACMB and ADM(1.3, 0.217mg/kg) respectively. The rest one group was treated with normal saline as a control group by daily i. p. injection for 7 days consecutively.The results showed that leucopenia of the rats in 1/10 LD50 groups were significant, polymorphonuclear leucocytes and BMC were decreased significantly and gr-anulocyte was also inhibited markedly, but there were no any significant changes seen in WBC and BMC of the rats in 1/10 LD50 ACMB groups.Like ADM, ACMB also showed a more acute toxicity to rats than ACMA did, however, the effect of ACMB on the hemogenesis function of rats is less than that of ACMA and ADM.更多还原