【摘要】 1984年9月于江苏省盱眙县境分离一恶性疟原虫虫株,暂定名为FCC-102/JS株连续培养观察52天生长良好。其96小时培养原虫平均增殖倍数为3.83±1.13倍,较海南岛株低(FCC-1/HN株为10.03±0.88,FCC-4/HN株为9.85±0.38)。该株配子体多见,平均占11.65±3.11％。用兔血清代替人血清不易生长。体外微量药效测定氯喹对FCC-102/JS株的半数有效浓度为42.03(28.51-61.95)nM,提示该株为氯喹敏感株,可作为抗原分析、研制疫苗及微量药效测定用的原虫模型。更多还原

【Abstract】 A new strain of Plasmodium falciparum was isolated from Jiangsu, China and coded FCC102/JS in continuous cultivation for a period of 52 days by Trager-Jensen’s Candle Jar method with gametocytes found over the whole period (Table 1). This strain differed distinctly in growth rates from FCC1/HN and FCC4/HN isolated from Hainan Island. The mean multiplication rate in 96 hrs of FCC102/JS was 3.83 ±1.13,while that of FCC1/BN and FCC4/HN was 10.03 ±0.88 and 9.85 ±0.38,respectively. The results of 48 hrs in vitro microtechnique showed that FCC102/JS was sensitive to chloroquine with a mean IC50 of 42.03(28.51-61.95) nM (Table 2). It was suggested that there may be some biological differences between FCC102/JS strain and FCC1/HN as well as between FCC102/JS and FCC4/HN strain.更多还原