【摘要】 本实验采用低叶酸、低浓度小牛血清培养条件,染色体G显带方法,研究30例鼻咽癌患者和22例正常人外周血细胞染色体畸变和脆性部位。结果表明:鼻咽癌患者染色体结构畸变率和脆性部位检出数明显高于正常人,有癌家族史患者染色体畸变率明显高于非癌家族史患者。更多还原

【Abstract】 TG 199 mediun of low concentration of folie acid (0.01mg/L) with 5% calf serum for peripheral lymphocyte culture and G-banding analysis of chromosome were used in this experiment. Chromosome aberration and fragile sites from 30 patients with NPC and 2 healthy controls were studied. The results were; 1.The chromosome structural aberration rate of the samples from the patients (11.10%) was higher than those of the control group (0.95%) significantly (P<0.001). 2.The chromosome aberration rate of 5 patients from the mily with other cancer patients was much higher than those without other cancer patients (P<0.01). 3.Total of 45 fragile sites (220 times)were observed, 20 of them coincide with known oncogene sites and 9 chromosomal rearrangements were found in 9 patients. The implication of chromosome aberration and fragile sites in NPC was discussed.更多还原